Tulearin A is a representative marine macrolide that was isolated by Kashman and coworkers in 2008. Bioguided separation (brine shrimp set) of the CHCl3/CH3OH (1:1) extract of Madagascar Fascaplysinopsis sp. sponge collected in Salary Bay north of Tulear provided 6.6 mg of 18-membered macrolactone, tulearin A, in yield of 0.019 wt %. Until now, there is no total synthesis of tulearin A. In 2009, one stereoisomer (C2-epi, C15-epi) of tulearin A was synthesized by Cossy, Curran and co-workers.
1. Bishara, A.; Rudi, A.; Aknin, M.; Neumann, D.; Ben-Califa, N.; Kashman, Y. Org. Lett. 2008, 10, 153.
2. Mandel, A. L.; Bellosta, V.; Curran, D. P.; Cossy, J. Org. Lett. 2009, 11, 3282.