Sch725675

Jared Moretti

Sch725674 is a novel macrolide isolated from the culture of an Aspergillus sp. by a team of researchers at Schering-Plough in 2005. The compound showed inhibitory activity against Saccharomyces cerevisiae (PM503) and Candida albicans (C43) with MICs of 8 and 32 mg/ml (micrograms per milliliter), respectively. The 2D structure of Sch725674 was rigorously assigned via 2D NMR data analyses including HSQC, HSQC-TOCSY, and HMBC. However, the stereochemistry of the four oxygenated methine carbon atoms could not be assigned due to the limited amount of sample isolated (about 1 mg). Fourteen-membered macrolactones lacking methyl substitution like Sch725674 are very rare in nature, which makes stereoisomer library generation more interesting in the context of structural assignment and biological evaluation.

Reference:

Journal of Antibiotics 58 (8): 535-538, 2005.