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Meloscine

Meloscine Hanmo
Hanmo Zhang


Meloscine, a representative member of Melodinus alkaloids, was isolated from the New Caledonian plant Melodinus Scandens Forst. Its structural uniqueness is represented by the existence of a dihydroquiloline-2-one moiety within the monoterpenoid Aspidosperma alkaloid skeleton. We are pursuing the total synthesis of meloscine via a chirality-transfer radical cyclization methodology, which was previously developed in our laboratory.